Pharm Ingredients
Wholesale Pure Natural Betulin Powder
White Birch Bark Extract Betulin Powder
KINTAI is a leading herbal extract manufacturer in China, specializing in high-quality Birch Bark Extract Betulin Powder. With certifications in cGMP, ISO, and HACCP, we provide premium bulk birch bark extract powder, offering purities up to 98% for both Betulin, as verified by HPLC.
We offer free samples, fast delivery, and customized services to meet your specific needs. Our products are manufactured under strict GMP standards, ensuring top-tier quality, and are highly popular in over 10 countries.
If you want to buy bulk and pure betulin powder, contact us directly—we’re here to provide you with exceptional products and services!
If you want to buy bulk and pure betulin powder, contact us directly—we’re here to provide you with exceptional products and services!
What is Betulin
Betulin is the primary active ingredients in birch bark extract powder, with our high-purity 98% extract being highly sought after in the medical, cosmetic, and healthcare industries. These compounds are naturally found in plants such as birch bark, jujube seeds, asparagus, pomegranate bark and leaves, and basil, with the highest concentration present in birch bark.
Source birch plant:
White birch is a deciduous tree of the genus Betula in the family Betulaceae.
Appearance:
The birch tree can grow up to 27 meters tall. The medical part of betulin is its bark and branches. Its bark is grayish white, the branches are dark gray or dark brown, and hairless. The leaves are triangular-ovate, triangular-rhombus, triangular. The flowering period is from May to June, and the fruiting period is from August to September in China.
Distribution area:
White birch is native to northern China. In addition to China, it also grows in Siberia, Russia, eastern Mongolia, northern Korea, and Japan.
Medicinal Value:
Birch has long been valued for its medicinal properties. Traditional Chinese medicine texts highlight birch bark for its ability to clear heat and dampness, eliminate phlegm, relieve coughs, detoxify, and reduce swelling. In ancient China, physicians commonly used birch bark to treat conditions such as tonsillitis, bronchitis, enteritis, dysentery, coughs, asthma, and various lung diseases.
Also, with the advantage of factory direct best price, our pure 98% birch bark extract betulin powder is hot sale in many countries as pharm active ingredients
The extraction process of betulin
cGMP approved manufacturer birch bark extract
Product Quality Standard of Betulin
| Product name | Betulin Powder |
|---|---|
| Extract source | Birch bark |
| Extraction Solvent | Ethyl alcohol |
| Appearance | White powder |
| Solubility | Solubility: soluble in ethanol, chloroform, benzene, slightly soluble in cold water, petroleum ether, etc. |
| Identification | HPLC, TLC |
| Sulphated Ash | NMT 0.5% |
| Heavy metals | NMT 20 PPM |
| Loss On Drying |
NT 5.0%
|
| Powder size | 80Mesh, NLT90% |
| Assay of Betulin Birch Bark (HPLC test, percent, Standard in House) |
Min. 95.0%
|
| Residual Solvents | |
| - N-hexane | NMT 290 PPM |
| - Methanol | NMT 3000 PPM |
| - Acetone |
NMT 5000 PPM
|
| - Ethyl Acetate | NMT 5000 PPM |
| - Ethanol | NMT 5000 PPM |
| Pesticide Residues | |
| - Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT) | NMT 0.05 PPM |
| - Aldrin, Endrin, Dieldrin | NMT 0.01 PPM |
| Microbiological Quality (Total viable aerobic count) | |
| - Bacteria, CFU/g, not more than | NMT 10³ |
| - Moulds and yeasts, CFU/g, not more than | NMT 10² |
| - E.coli, Salmonella, S. aureus, CFU/g | Absence |
| Storage | In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine. |
| Shelf life | 2 years |
Physical and chemical properties
| CAS | No: 473-98-3 |
|---|---|
| Density | 1.0±0.1 g/cm3 |
| Melting Point | 256-257 °C(lit.) |
| Molecular Formula | C30H50O2 |
| Molecular Weight | 442.717 |
| Flash Point | 210.9±17.2 °C |
| Exact Mass | 442.381073 |
| PSA | 40.46000 |
| LogP | 9.01 |
| Vapor Pressure | 0.0±3.1 mmHg at 25°C |
| Mark | Otto |
| Index of Refraction | 1.525 |
| Storage condition | 2-8°C |
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Betulin Benefits
Hepatoprotective：Betulin exhibits therapeutic effects on alcoholic fatty liver disease in rats. It significantly alleviates alcohol-induced hepatic steatosis and necrosis, inhibits lipid peroxidation damage in liver tissue caused by alcohol, and demonstrates favorable efficacy in treating alcoholic liver injury.
Anti-cancer and anti-tumor effects：Betulin exhibits inhibitory effects on various cancer cell types, including RCC4, DLD-1, PC-3, HeLa, SK-HEP-1, HepG2, A549, and MCF-7 cells, as well as cervical cancer cell lines. It promotes tumor cell apoptosis and exerts anti-tumor activity by inducing mitochondrial-related apoptotic pathways.
Anti-HIV Effects：The main active component of birch bark, betulin, can be chemically modified into potent anti-HIV drugs, making it a valuable medicinal resource. The three major triterpenoids in white birch are betulinic acid, betulin, and lupeol. These compounds and their derivatives exhibit significant anti-tumor and anti-inflammatory activities, along with inhibitory effects on both HIV protease and reverse transcriptase. Their mechanisms of action target nearly every stage of the viral life cycle, though most compounds primarily inhibit the viral adsorption phase.
Hypolipidemic Effects：Betulin exhibits significant pharmacological effects against hyperlipidemia, effectively reducing both blood cholesterol and triglyceride levels. Additionally, it inhibits the function of sterol regulatory element-binding protein (SREBP), thereby modulating cholesterol metabolism. Notably, betulin can significantly decrease serum levels of triglycerides, free fatty acids, and cholesterol. These effects improve hyperlipidemia and insulin resistance in obese patients, demonstrating therapeutic potential for type II diabetes mellitus
Anti-inflammatory and Antioxidant Effects：Betulin and betulinic acid exhibit anti-inflammatory activity at high concentrations, likely through protein kinase C inhibition rather than neurogenic mechanisms. These compounds show therapeutic potential in various inflammatory conditions, including acute lung injury (reducing LPS-induced pro-inflammatory factors, myeloperoxidase activity, and bacterial load).
Additionally, betulin demonstrates antioxidant properties, protecting against radiation damage (via free radical scavenging) and adriamycin-induced cardiotoxicity (through oxidative stress inhibition).
Why Choose Betulin by Kintaibio®?
1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce betulin powder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.
